“Moisturizing the hands regularly can help improve the overall appearance of skin however, it’s important to remember that similar anti-aging ingredients can be used on the hands as are used on the face,” she says. Garshick suggests choosing options with “humectants like hyaluronic acid and glycerin that hydrate, emollients such as squalene to help soften and smooth, ceramides to strengthen the skin, and occlusives like petrolatum-which provide a barrier to protect the hands from external irritants.” And for those worried about fine lines and dark spots, she mentions there are a variety of formulas to address those, too. When shopping for the best hand creams, Dr.